Up-regulation of FOS-like antigen 1 contributes to neuronal apoptosis in the cortex of rat following traumatic brain injury

@article{Xu2017UpregulationOF,
  title={Up-regulation of FOS-like antigen 1 contributes to neuronal apoptosis in the cortex of rat following traumatic brain injury},
  author={Xide Xu and Rui Jiang and Peipei Gong and Qianqian Liu and Yinan Chen and Shiqiang Hou and Debin Yuan and Jiansheng Shi and Qing Lan},
  journal={Metabolic Brain Disease},
  year={2017},
  volume={33},
  pages={115-125}
}
Neuronal apoptosis is an important process of secondary brain injury which is induced by neurochemical signaling cascades after traumatic brain injury (TBI). Present study was designed to investigate whether FOS-like antigen 1 (Fra-1) is involved in the neuronal apoptosis. Western blot analysis and immunohistochemistry in a rat TBI model revealed a significant increase in the expression of Fra-1 in the ipsilateral brain cortex, which was in parallel with increase in the expression of active… CONTINUE READING
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