Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.

@article{Hosoi2004UpregulationOD,
  title={Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.},
  author={Yoshio Hosoi and Toshiaki Watanabe and Keiichi Nakagawa and Yoshihisa Matsumoto and Atsushi Enomoto and Akinori Morita and Hirokazu Nagawa and Norio Suzuki},
  journal={International journal of oncology},
  year={2004},
  volume={25 2},
  pages={461-8}
}
Tumor tissues and adjacent normal tissues in 12 colorectal cancers were examined for quantitative differences in: i) activity of DNA-dependent protein kinase (DNA-PK), which functions in DNA double-strand breads repair, and ii) protein and mRNA levels of Ku70, Ku80, DNA-PKcs and transcriptional factor Sp1. DNA-PK activity and protein/mRNA levels of Ku70, Ku80, DNA-PKcs and Sp1 were significantly higher in the tumor tissues compared with the normal tissues. Significant correlations between DNA… CONTINUE READING

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