Up-regulation of Bcl-xL expression protects CD40-activated human B cells from Fas-mediated apoptosis.

@article{Zhang1996UpregulationOB,
  title={Up-regulation of Bcl-xL expression protects CD40-activated human B cells from Fas-mediated apoptosis.},
  author={Xin Zhang and Liwu Li and Jongseon Choe and Stanislaw Krajewski and John C. Reed and Charles B. Thompson and Yong Sung Choi},
  journal={Cellular immunology},
  year={1996},
  volume={173 1},
  pages={149-54}
}
CD40--CD40L interactions between resting B cells and activated T cells are essential for germinal center formation. It has been shown that CD40L can induce both Fas expression and susceptibility to Fas-mediated killing in B cells, while anti-Ig can partially rescue B cells from Fas-mediated killing. However, the intracellular mechanism for this phenomenon is not known. We examined the expression of Fas and bcl-2 family gene products, such as Bcl-2, Bcl-x, Bax, and Mcl-1, in human tonsillar B… CONTINUE READING

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