Up-regulation by human recombinant transforming growth factor beta-1 of collagen production in cultured dermal fibroblasts is mediated by the inhibition of nitric oxide signaling.

@article{Chu1999UpregulationBH,
  title={Up-regulation by human recombinant transforming growth factor beta-1 of collagen production in cultured dermal fibroblasts is mediated by the inhibition of nitric oxide signaling.},
  author={Arthur J. Chu and Jai Kishan Prasad},
  journal={Journal of the American College of Surgeons},
  year={1999},
  volume={188 3},
  pages={271-80}
}
BACKGROUND Hypertrophic scarring remains the most disabling sequela for burn survivors. Little is known about its pathogenesis. Collagen accumulation, however, has been consistently observed in burn hypertrophic scars (HS). STUDY DESIGN We have studied collagen production in the dermal fibroblasts derived from HS, which has developed for 9 months to 2… CONTINUE READING