Up-regulation and trafficking of δ opioid receptor in a model of chronic inflammation: implications for pain control

@article{Cahill2003UpregulationAT,
  title={Up-regulation and trafficking of δ opioid receptor in a model of chronic inflammation: implications for pain control},
  author={Catherine M Cahill and Anne Morinville and Cyrla Hoffert and Dajan O'donnell and Alain Beaudet},
  journal={Pain},
  year={2003},
  volume={101},
  pages={199-208}
}
Pharmacological and physiological evidence supports a role for delta (delta) opioid receptors in the nociceptive mechanisms of inflammation. However, few data exist regarding delta opioid receptor expression and localization in such conditions. In this study, we have assessed the distribution and function of delta opioid receptors in the rat spinal cord following induction of chronic inflammation by intraplantar injection of complete Freund's adjuvant (CFA). Intrathecal administration of the… CONTINUE READING
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