Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells.

@article{Mauln2003UpregulationAP,
  title={Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells.},
  author={Nancy P Maul{\'e}n and Esther A Henr{\'i}quez and Sybille Kempe and Juan G C{\'a}rcamo and Alexandra Schmid-Kotsas and Max Georg Bachem and Adolph Gr{\"u}nert and Marcelo E Bustamante and Francisco Nualart and Juan Vera},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 11},
  pages={9035-41}
}
Human cells acquire vitamin C using two different transporter systems, the sodium-ascorbic acid co-transporters with specificity for ascorbic acid, and the facilitative glucose transporters with specificity for dehydroascorbic acid. There is no information on the mechanism of vitamin C transport across the intestinal barrier, a step that determines the bioavailability of vitamin C in humans. We used the colon carcinoma cell line CaCo-2 as an in vitro model for vitamin C transport in enterocyte… CONTINUE READING