Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death.

@article{Pannaccione2007UpregulationAI,
  title={Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death.},
  author={Anna Pannaccione and Francesca Boscia and Antonella Scorziello and Annagrazia Adornetto and Pasqualina Castaldo and Rossana Sirabella and Maurizio Taglialatela and Gianfranco F Di Renzo and Lucio Annunziato},
  journal={Molecular pharmacology},
  year={2007},
  volume={72 3},
  pages={665-73}
}
The aim of the present study was to investigate whether K(V)3.4 channel subunits are involved in neuronal death induced by neurotoxic beta-amyloid peptides (Abeta). In particular, to test this hypothesis, three main questions were addressed: 1) whether the Abeta peptide can up-regulate both the transcription/translation and activity of K(V)3.4 channel… CONTINUE READING