Up-regulation and Cytoprotective Role of Epithelial Multidrug Resistance-associated Protein 1 in Inflammatory Bowel Disease*

@article{Blokzijl2008UpregulationAC,
  title={Up-regulation and Cytoprotective Role of Epithelial Multidrug Resistance-associated Protein 1 in Inflammatory Bowel Disease*},
  author={Hans Blokzijl and Axel van Steenpaal and Sara Vander Borght and Lisette Bok and Louis Libbrecht and Marieke Tamminga and Mariska Geuken and Tania A. Roskams and Gerard Dijkstra and Han Moshage and Peter L. M. Jansen and Klaas Nico Faber},
  journal={Journal of Biological Chemistry},
  year={2008},
  volume={283},
  pages={35630 - 35637},
  url={https://api.semanticscholar.org/CorpusID:9488690}
}
Data show that MRP1 protects intestinal epithelial cells against inflammation-induced apoptotic cell death and provides a functional role for MRp1 in the inflamed intestinal epithelium of IBD patients.
View on ASBMB
jbc.org
44 Citations
Highly Influential Citations
3
Background Citations
14
Results Citations
1

Figures from this paper

44 Citations

Function and regulation of the multidrug resistance-associated protein 1 during inflammatory bowel disease and liver regeneration

Data show that MRP1 protects intestinal epithelial cells against inflammation-induced apoptotic cell death and provides a functional role for MRp1 in the inflamed intestinal epithelium of IBD patients.

Reduction of MDR1, MRP1 and BCRP expression in Crohn’s disease: a role in disease pathogenesis?

Reduced MDR1 expression, irrespective of the disease group, and reduced MRP1 expression in untreated group, implicates the involvement of these transporters in the disease pathogenesis.

2018-0705 Transporters MRP 1 and MRP 2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection

It is shown that epitheliumderived MRP1 and MRP2 efflux immunomodulatory agents that assist in controlling passage of neutrophils during infection and that limiting neutrophil infiltration produced less bacteremia and better survival during murine infection.

Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection

This work shows that epithelium-derived MRP1 and MRP2 efflux immunomodulatory agents that assist in controlling passage of neutrophils during infection and that limiting neutrophil infiltration produced less bacteremia and better survival during murine infection, and is the first to identify an MRP 1/MRP2 axis of neutophil control in the lung.

Multidrug Resistance Protein 1 (MRP1, ABCC1), a “Multitasking” ATP-binding Cassette (ABC) Transporter*

It is clear that MRP1 serves a broader role than simply mediating the ATP-dependent efflux of drugs from cells, and is a multitasking transporter that likely influences the etiology and progression of a host of human diseases.

The Role of Eukaryotic ABC-Transporters in Eliciting Neutrophil infiltration during Streptococcus pneumoniae infection

It is demonstrated that MRP1 and MRP2 are divergent ABCtransporters that control transepithelial PMN migration through efflux of a distinct antiinflammatory substance and the pro-inflammatory HXA3 in the context of Streptococcus pneumoniae infection.

The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells.

Chapter 3 ciGarette smoke enhances resistance to apoptosis ; relevance for its opposite effects in inflammatory Bowel Diseases

Gene-environment interactions in Inflammatory Bowel Disease

Signifi cant cytoprotective action of nicotine at concentrations similar to concentrations found in blood of smokers is shown, however, confl icting data of therapeutic eff ects of nicotine exists and other compounds may contribute more to the cytoprotective action of smoke.

Implication of ABC transporters in non-proliferative diseases.

48 References

Differential Susceptibility of Multidrug Resistance Protein-1 Deficient Mice to DSS and TNBS-Induced Colitis

It is concluded that MRP-1 has an important role in the intestinal epithelial resistance to exogenous injury, but MRp-1 does not affect T-lymphocyte mediated mucosal damage.

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

The results suggest that this ubiquitous GS-X pump, which mediates the cellular excretion of many drugs, glutathione S-conjugates of lipophilic xenobiotics and endogenous cysteinyl leukotrienes, is dispensable in mice, making treatment of MDR with MRP-specific reversal agents potentially feasible.

Implication of TNF-related apoptosis-inducing ligand in inflammatory intestinal epithelial lesions.

TRAIL is a new inflammatory mediator implicated in the homeostasis of intestinal epithelial barrier functions and is highly up-regulated in IEC in inflammatory ileum and colon.

Tissue distribution of the multidrug resistance protein.

The presence of MRP in bronchiolar epithelium, heart muscle, and macrophages would agree with the glutathione S-conjugate carrier activity previously detected in these cells, and in 46 of 119 untreated tumors from various histogenetic origins MRP staining was seen.

Glutathione Export during Apoptosis Requires Functional Multidrug Resistance-associated Proteins*

GSH release in Jurkat cells undergoing apoptosis was inhibited by the organic anion transport inhibitors MK571, sulfinpyrazone, and probenecid, supporting a role for the MRP transporters in this process and providing direct evidence that MRP1 is involved in GSH export.

Decreased P‐glycoprotein (P‐gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels

MDR1 expression is strongly decreased in inflamed IE of patients with gastrointestinal disorders and this is independent of PXR protein levels, suggesting low MDR1 levels may aggravate intestinal inflammation.

The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation.

In this review, current knowledge of the biochemical, physiological and pharmacological properties of nine members of the multidrug resistance protein (MRP)-related ABCC family as well as the G family member, ABCG2/BCRP, are summarized.

SLCO/OATP-like Transport of Glutathione in FasL-induced Apoptosis

Results suggest that GSH efflux during FasL-induced apoptosis is mediated by a SLCO/OATP-like transport mechanism that modulates the progression of the execution phase of apoptosis.

Expression and Function of Death Receptors and Their Natural Ligands in the Intestine

Although it is unlikely that the CD95/CD95L system is involved in the physiologic regeneration of the intestinal epithelium, this system may play an important role in the pathogenesis of inflammatory bowel diseases.

Structural, mechanistic and clinical aspects of MRP1.