Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration.

@article{MacasSilva2002UpregulatedTR,
  title={Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration.},
  author={Marina Mac{\'i}as-Silva and Wei Li and Julia I-Ju Leu and Mary Ann S. Crissey and Rebecca Taub},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 32},
  pages={28483-90}
}
Transforming growth factor-beta (TGF-beta) functions as an antiproliferative factor for hepatocytes. However, for unexplained reasons, hepatocytes become resistant to TGF-beta signals and can proliferate despite the presence of TGF-beta during liver regeneration. TGF-beta is up-regulated during liver regeneration, although it is not known whether it is active or latent. TGF-beta activity may be examined by assessing Smad activation, a downstream signaling pathway. Smad pathway activation during… CONTINUE READING