Up-regulated proteins in the fluid bathing the tumour cell microenvironment as potential serological markers for early detection of cancer of the breast.

@article{Gromov2010UpregulatedPI,
  title={Up-regulated proteins in the fluid bathing the tumour cell microenvironment as potential serological markers for early detection of cancer of the breast.},
  author={Pavel S Gromov and Irina A. Gromova and Jakob Bunkenborg and T. Izco Cabez{\'o}n and Jose A. Moreira and Vera Timmermans-Wielenga and Peter Roepstorff and Fritz E Rank and J. E. Celis},
  journal={Molecular oncology},
  year={2010},
  volume={4 1},
  pages={
          65-89
        }
}
Breast cancer is by far the most common diagnosed form of cancer and the leading cause of cancer death in women today. Clinically useful biomarkers for early detection of breast cancer could lead to a significant reduction in mortality. Here we describe a detailed analysis using gel-based proteomics in combination with mass spectrometry and immunohistochemistry (IHC) of the tumour interstitial fluids (TIF) and normal interstitial fluids (NIF) collected from 69 prospective breast cancer patients… CONTINUE READING
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