Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancers.

@article{Malentacchi2005UpregulatedEO,
  title={Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancers.},
  author={Francesca Malentacchi and Riccardo Marzocchini and Stefania Gelmini and C. James Orlando and Mario Serio and G. Manao G. Ramponi and Giovanni Raugei},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={334 3},
  pages={875-83}
}
Protein tyrosine phosphorylation, mediated by the balanced action of tyrosine kinases and phosphatases, contributes to the regulation of the growth, migration, and invasion of normal and malignant cells. Among tyrosine phosphatases, low molecular weight protein tyrosine phosphatases (LMW-PTP) have been recognized as a possible "positive factor" in tumour onset and progression. The aim of this work was to assess whether LMW-PTP are differentially expressed in normal and malignant tissues. Using… CONTINUE READING

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