Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.

@article{Komatsuda2008UpregulatedEO,
  title={Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.},
  author={Atsushi Komatsuda and Hideki Wakui and Keiko Iwamoto and Madoka Ozawa and Masaru Togashi and Rie Masai and Nobuki Maki and Tsuyoshi Hatakeyama and Ken-ichi Sawada},
  journal={Clinical and experimental immunology},
  year={2008},
  volume={152 3},
  pages={482-7}
}
Recent studies in animal models for systemic lupus erythematosus (SLE) have shown that Toll-like receptors (TLR-7 and TLR-9) and interferon (IFN)-alpha are involved in the pathogenesis of murine lupus. Recent studies using flow cytometry have also shown increased expression of TLR-9 in peripheral blood mononuclear cells (PBMCs) from SLE patients. In this study, we performed quantitative real-time reverse transcription-polymerase chain reaction analyses of PBMCs from 21 SLE patients and 21… CONTINUE READING
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Systemic lupus erythematosus

  • MA Khamashta, Hughes GRV
  • Lancet
  • 2007

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