Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis.

Abstract

OBJECTIVE Rheumatoid arthritis (RA) is a chronic inflammatory condition characterized by a cellular influx and destruction of the joint architecture. Chemokines characteristically regulate leukocyte recruitment and activation. Chemokine (CC motif) receptor-like 2 (CCRL2) is an orphan receptor with homology to other CC chemokine receptors. We undertook this… (More)

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