Up-regulated delta 9-desaturase gene expression by hypolipidemic peroxisome-proliferating fatty acids results in increased oleic acid content in liver and VLDL: accumulation of a delta 9-desaturated metabolite of tetradecylthioacetic acid.

@article{Madsen1997UpregulatedD9,
  title={Up-regulated delta 9-desaturase gene expression by hypolipidemic peroxisome-proliferating fatty acids results in increased oleic acid content in liver and VLDL: accumulation of a delta 9-desaturated metabolite of tetradecylthioacetic acid.},
  author={Lauren Madsen and Livar Fr{\o}yland and Hans J. Grav and Rolf Kristian Berge},
  journal={Journal of lipid research},
  year={1997},
  volume={38 3},
  pages={
          554-63
        }
}
In the liver of rats, monocarboxylic 3-thia fatty acids, tridecylthioacetic acid (C13-S-acetic acid) and tetradecylthioacetic acid (C14-S-acetic acid), increase the mRNA levels of delta 9-desaturase both in a time- and dose-dependent manner. The increased delta 9-desaturase mRNA levels were accompanied by increased delta 9-desaturase activity and increased amounts of oleic acid (18:1 n-9) and delta 9-desaturated C14-S-acetic acid. delta 9-Desaturated C14-S-acetic acid was only detected in… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 26 REFERENCES

Long term effect of tetradecyl - thioacetic acid : a study on lipid profile and fatty acid composition and oxidation in different rat organs

  • M Gottlicher, A. Demoz, P. Tollet, R. K. Berge, J-A. Gustafsson
  • Biochim . Biophys . Acta .
  • 1996

Impact of cytochrome P 450 system on lipoprotein metabolism . Effect of abnormal fatty acids ( bthia fatty acids )

  • R. M. Viscardi
  • 1994

Transcriptional control of the stearoyl - CoA desaturase - 1 gene by polyunsaturated fatty acids

  • R. K. Berge, E. Hvattum
  • Bip chem . Biophys . Res . Commun .
  • 1994

Effect of J-thiadicar

  • A. Al-Shurbaji, J. Skorve, R. K Berge, M. Rudling, I. Bjorkhem, L. Berglund
  • J. Lipid Res
  • 1993
1 Excerpt

On the mechanism of the hypolipidemic effect of sulfur-substituted hexadecanedoic acid (3thiadicarboxylic acid) in normolipidemic rats

  • J. Skorve, A. AlShurbaji, D. Asiedu, I. Bjorkhem, L. Berglund, R. K. Berge
  • J. Lipid Res
  • 1993
1 Excerpt

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