Up on the tightrope: natural killer cell activation and inhibition

@article{Lanier2008UpOT,
  title={Up on the tightrope: natural killer cell activation and inhibition},
  author={Lewis L. Lanier},
  journal={Nature Immunology},
  year={2008},
  volume={9},
  pages={495-502}
}
Natural killer (NK) cells circulate through the blood, lymphatics and tissues, on patrol for the presence of transformed or pathogen-infected cells. As almost all NK cell receptors bind to host-encoded ligands, signals are constantly being transmitted into NK cells, whether they interact with normal or abnormal cells. The sophisticated repertoire of activating and inhibitory receptors that has evolved to regulate NK cell activity ensures that NK cells protect hosts against pathogens, yet… CONTINUE READING
Highly Influential
This paper has highly influenced 33 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS