Up-down determination of the 90% effective dose of phenylephrine for the treatment of spinal anesthesia-induced hypotension in parturients undergoing cesarean delivery.

@article{George2010UpdownDO,
  title={Up-down determination of the 90% effective dose of phenylephrine for the treatment of spinal anesthesia-induced hypotension in parturients undergoing cesarean delivery.},
  author={Ronald B George and Dolores Mckeen and Malachy Oliver Columb and Ashraf S Habib},
  journal={Anesthesia and analgesia},
  year={2010},
  volume={110 1},
  pages={154-8}
}
INTRODUCTION Hypotension frequently complicates spinal anesthesia for cesarean delivery, and vasopressors are the mainstay for treatment. The most effective dose of phenylephrine for the treatment of spinal anesthesia-induced hypotension has not been estimated. METHODS Healthy nonlaboring women undergoing a cesarean delivery were recruited. All women received spinal anesthesia using hyperbaric bupivacaine 12 mg with fentanyl and morphine. Each subject received an i.v. crystalloid fluid bolus… CONTINUE READING