Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice

@article{Toh2008UpRegulationOM,
  title={Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice},
  author={Shen Yon Toh and Jingyi Gong and Guoli Du and John Z. Li and Shuqun Yang and Jing Ye and Huilan Yao and Yinxin Zhang and Bofu Xue and Qing Li and Hongyuan Yang and Zilong Wen and Peng Li},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={401 - 408}
}
Fsp27, a member of the Cide family proteins, was shown to localize to lipid droplet and promote lipid storage in adipocytes. We aimed to understand the biological role of Fsp27 in regulating adipose tissue differentiation, insulin sensitivity and energy balance. Fsp27(-/-) mice and Fsp27/lep double deficient mice were generated and we examined the adiposity, whole body metabolism, BAT and WAT morphology, insulin sensitivity, mitochondrial activity, and gene expression changes in these mouse… CONTINUE READING

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