Up‐regulation of p27Kip1 Correlates Inversely with Anchorage‐independent Growth of Human Cancer Cell Lines

@inproceedings{Kawada1998UpregulationOP,
  title={Up‐regulation of p27Kip1 Correlates Inversely with Anchorage‐independent Growth of Human Cancer Cell Lines},
  author={Manabu Kawada and Yoshimasa Uehara and Satoshi Mizuno and Takao Yamori and Takashi Tsuruo},
  booktitle={Japanese journal of cancer research : Gann},
  year={1998}
}
We examined the correlation between anchorage-independent growth and cell cycle-related molecules using 39 human cancer cell lines. They consisted of lung-, colon-, stomach-, breast-, ovarian-, brain-, renal- and melanoma-derived cell lines. Their anchorage-independent growth ability varied, but was not clearly related to the tissue of origin. There was a tendency for the levels of cyclin D1, cyclin E, cyclin A, p27, and p21 to show a tissue-dependent expression pattern. Statistical analysis… CONTINUE READING