Unwinding the von Willebrand factor strings puzzle.

@article{Ceunynck2013UnwindingTV,
  title={Unwinding the von Willebrand factor strings puzzle.},
  author={Karen De Ceunynck and Simon F De Meyer and Karen Vanhoorelbeke},
  journal={Blood},
  year={2013},
  volume={121 2},
  pages={270-7}
}
von Willebrand factor (VWF) is amongst others synthesized by endothelial cells and stored as ultra-large (UL) VWF multimers in Weibel-Palade bodies. Although UL-VWF is proteolysed by ADAMTS13 (a disintegrin-like and metalloprotease domain with thrombospondin type-1 motif, number 13) on secretion from endothelial cells, in vitro experiments in the absence of ADAMTS13 have demonstrated that a proportion of these UL-VWF multimers remain anchored to the activated endothelium. These multimers… CONTINUE READING

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