Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen.

@article{Rocha2011UnveilingTS,
  title={Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen.},
  author={Rita de C{\'a}ssia Castelli da Rocha and Pedro Jos{\'e} Barbosa Pereira and Manuel A. S. Santos and Sandra Macedo-Ribeiro},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 34},
  pages={
          14091-6
        }
}
In a restricted group of opportunistic fungal pathogens the universal leucine CUG codon is translated both as serine (97%) and leucine (3%), challenging the concept that translational ambiguity has a negative impact in living organisms. To elucidate the molecular mechanisms underlying the in vivo tolerance to a nonconserved genetic code alteration, we have undertaken an extensive structural analysis of proteins containing CUG-encoded residues and solved the crystal structures of the two natural… CONTINUE READING
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