Unveiling the mystery of déjà vu: The structural anatomy of déjà vu

@article{Brzdil2012UnveilingTM,
  title={Unveiling the mystery of d{\'e}j{\`a} vu: The structural anatomy of d{\'e}j{\`a} vu},
  author={Milan Br{\'a}zdil and Radek Mare{\vc}ek and Tom{\'a}s Urb{\'a}nek and Tom{\'a}{\vs} Ka{\vs}p{\'a}rek and Michal Mikl and Ivan Rektor and Adam Zeman},
  journal={Cortex},
  year={2012},
  volume={48},
  pages={1240-1243}
}
Déjà vu (DV) is a widespread, fascinating and mysterious human experience. It occurs both in health and in disease, notably as an aura of temporal lobe epilepsy. This feeling of inappropriate familiarity has attracted interest from psychologists and neuroscientists for over a century, but still there is no widely agreed explanation for the phenomenon of non-pathological DV. Here we investigated differences in brain morphology between healthy subjects with and without DV using a novel… Expand
Comment on Brázdil (2012) “Unveiling the mystery of dèjà-vù: The structural anatomy of dèjà-vù”
TLDR
The authors are asked whether the healthy population recruited was fully investigated to exclude the diagnosis of TLE, and whether the anatomical and functional basis of epileptic and non-epileptic déjà vu shares a common physiology. Expand
Abnormal rsFC and GMV changes in parahippocampal and DLPFC for high Déjà vu experienced subjects
TLDR
Findings indicated that familiarity without recollection (PHG) and superior context monitoring (DLPFC) are critical for real-life déjà vu experiences. Expand
Neuro-anatomical differences among epileptic and non-epileptic déjà-vu
TLDR
VBM results demonstrated different morphologic patterns in individuals with epilepsy and control subjects experiencing DV, involving the memory circuit in bMTLE patients and cerebral regions in the emotional network in healthy controls. Expand
Structural covariance mapping delineates medial and medio-lateral temporal networks in déjà vu
TLDR
The present study assessed whether grey-matter covariance among structures implicated in non-pathological DV differs according to the frequency with which the phenomenon is experienced, and revealed two diverging patterns of structural covariation. Expand
Functional activity changes in memory and emotional systems of healthy subjects with déjà vu
TLDR
This study demonstrates that individuals who experienced DV are not characterized by different performance underlying familiarity/recollection memory processes, and fMRI results provide evidence that the physiological DV experience is associated with the employment of different neural responses of brain regions involved in memory and emotional processes. Expand
Hippocampal involvement in nonpathological déjà vu: Subfield vulnerability rather than temporal lobe epilepsy equivalent
TLDR
The hypothesis that hippocampal involvement in nonpathological DV resembles more closely the pattern of GMV decrease observed in MTLE compared with that occurring in SCH is tested. Expand
Pathophysiology of Déjà Vu and Reminiscences in Epilepsy
Illusions of inappriopriate familiarity with the current experience or hallucinatory recall of memories have been reported in temporal lobe epilepsies. Pathophysiological hypotheses have been putExpand
Is there anything distinctive about epileptic déjà vu?
Background Déjà vu can occur as an aura of temporal lobe epilepsy and in some psychiatric conditions but is also common in the general population. It is unclear whether any clinical featuresExpand
Déjà vu and prescience in a case of severe episodic amnesia following bilateral hippocampal lesions
TLDR
This study shows that déjà vu can occur in cases of amnesia with massively damaged hippocampi and confirms that the perirhinal region is a core region for déjé vu, using a different approach from previous reports. Expand
Many Faces of Déjà Vu: a Narrative Review.
TLDR
It seems that temporal region is the origin of déjà vu phenomena in both healthy individuals and in individuals with neurological and psychiatric conditions, but the exact mechanism of this phenomenon is however still unknown. Expand
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References

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Neuroimaging and cognitive changes during déjà vu
TLDR
The results confirm the role of mesiotemporal structures in the pathogenesis of DV and hypothesize that individual neuroanatomy and disturbances in gamma oscillations or in the dopaminergic system played a role in DBS-elicited DV in a 22-year-old woman treated with deep brain stimulation for hemidystonia. Expand
Anatomical origin of déjà vu and vivid 'memories' in human temporal lobe epilepsy.
TLDR
The mental phenomena observed in epileptic patients with electrodes stereotaxically implanted into different brain areas for seizure localization prior to surgical treatment is considered, finding that the amygdala was involved in 73% of cases, the anterior hippocampus in 83% and the temporal neocortex in 88%. Expand
Cortical stimulation study of the role of rhinal cortex in déjà vu and reminiscence of memories
TLDR
This study strongly suggests that experiential symptoms are largely dependent upon functional modification of the physiology of the rhinal cortices. Expand
Déjà-vu in temporal lobe epilepsy: Metabolic pattern of cortical involvement in patients with normal brain MRI
TLDR
Findings argue for metabolic dysfunction of a medial-lateral temporal network in patients with déjà-vu and normal brain MRI and suggest that the feeling of familiarity during seizures greatly depends on alteration of the recognition memory system. Expand
A review of the déjà vu experience.
TLDR
Systematic research is needed on the prevalence and etiology of this culturally familiar cognitive experience, and several laboratory models may help clarify this illusion of recognition. Expand
Voxel‐based morphometry of temporal lobe epilepsy: An introduction and review of the literature
TLDR
It is unlikely that VBM has any clinical utility given the lack of robustness for individual comparisons, however, VBM may help elucidate some unresolved important research questions such as how recurrent temporal lobe seizures affect hippocampal and extrahippocampal morphology using serial imaging acquisitions. Expand
Two forms of déjà vu experiences in patients with epilepsy
TLDR
Two forms of déjà vu experiences in persons with epilepsy are clarified, which are differently associated with their seizure recognition. Expand
Demographic and Psychological Features of Déjà Vu Experiences in a Nonclinical Japanese Population
TLDR
Results suggest that déjà vu experiences are associated with good memory function and associated with depersonalization, derealization, jamais vu, and daydreams. Expand
Recognition Without Identification, Erroneous Familiarity, and Déjà Vu
TLDR
The need for more experimentation and a more cautious interpretation of research findings is suggested, particularly as many techniques being used to explore déjà vu are in the early stages of development. Expand
Source‐based morphometry of gray matter volume in men with first‐episode schizophrenia
TLDR
Using SBM, multivariate analysis of gray matter volume seems to be a suitable method for characterization of the pattern of changes at the beginning of the illness in schizophrenia subjects. Expand
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