Unveiling Contacts within Macromolecular Assemblies by Solving Minimum Weight Connectivity Inference (MWC) Problems.

@article{Agarwal2015UnveilingCW,
  title={Unveiling Contacts within Macromolecular Assemblies by Solving Minimum Weight Connectivity Inference (MWC) Problems.},
  author={Deepesh Agarwal and Christelle Caillouet and David Coudert and Fr{\'e}d{\'e}ric Cazals},
  journal={Molecular & cellular proteomics : MCP},
  year={2015},
  volume={14 8},
  pages={2274-84}
}
Consider a set of oligomers listing the subunits involved in subcomplexes of a macromolecular assembly, obtained e.g. using native mass spectrometry or affinity purification. Given these oligomers, connectivity inference (CI) consists of finding the most plausible contacts between these subunits, and minimum connectivity inference (MCI) is the variant consisting of finding a set of contacts of smallest cardinality. MCI problems avoid speculating on the total number of contacts but yield a… CONTINUE READING

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