Unusual variants of Alexander's disease.

  title={Unusual variants of Alexander's disease.},
  author={Marjo S. van der Knaap and Gajja Sophi Salomons and Rong Li and Emilio Franzoni and Luiz Gonz{\'a}lez Guti{\'e}rrez-Solana and Leo M. E. Smit and R Robinson and Collin D Ferrie and Bruce A. C. Cree and A Malla Reddy and Neil Thomas and Brenda Banwell and Frederik Barkhof and Cornelis Jakobs and Anne E. Johnson and Albee Messing and Michael Brenner},
  journal={Annals of neurology},
  volume={57 3},
The purpose of this study was to describe unusual variants of Alexander's disease. We studied 10 patients who did not meet previously established magnetic resonance imaging (MRI) criteria for Alexander's disease, but for whom this diagnosis was considered because of Rosenthal fibers at histological examination or presence of some MRI features suggestive of Alexander's disease. Sequence analysis of the GFAP gene was performed. In eight patients, MRI results showed predominantly posterior fossa… CONTINUE READING