Unusual synthesis of new glycine antagonists via sequential aldol condensation-lactonization-elimination reaction.

@article{Giacobbe1998UnusualSO,
  title={Unusual synthesis of new glycine antagonists via sequential aldol condensation-lactonization-elimination reaction.},
  author={Simone Giacobbe and Davide Baraldi and Romano di Fabio},
  journal={Bioorganic & medicinal chemistry letters},
  year={1998},
  volume={8 13},
  pages={1689-92}
}
Compounds 2 and 3 were designed in order to probe the North-East region of the strichnine-insensitive glycine binding site of the NMDA receptor. The two products were obtained readily by a tandem aldol condensation-lactonization-elimination step which affords the desired E isomer with complete regioselection.