Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP.

  title={Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP.},
  author={P. F. van der Ven and E. Ehler and Padmanabhan Vakeel and Stefan Eulitz and J. A. Schenk and H. Milting and B. Micheel and D. F{\"u}rst},
  journal={Experimental cell research},
  volume={312 11},
  • P. F. van der Ven, E. Ehler, +5 authors D. Fürst
  • Published 2006
  • Medicine, Biology
  • Experimental cell research
  • Filamin c is the predominantly expressed filamin isoform in striated muscles. It is localized in myofibrillar Z-discs, where it binds FATZ and myotilin, and in myotendinous junctions and intercalated discs. Here, we identify Xin, the protein encoded by the human gene 'cardiomyopathy associated 1' (CMYA1) as filamin c binding partner at these specialized structures where the ends of myofibrils are attached to the sarcolemma. Xin directly binds the EVH1 domain proteins Mena and VASP. In the adult… CONTINUE READING
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