Unusual properties of Plasmodium falciparum actin: new insights into microfilament dynamics of apicomplexan parasites.

@article{Schler2005UnusualPO,
  title={Unusual properties of Plasmodium falciparum actin: new insights into microfilament dynamics of apicomplexan parasites.},
  author={Herwig Sch{\"u}ler and A Mueller and Kai Matuschewski},
  journal={FEBS letters},
  year={2005},
  volume={579 3},
  pages={655-60}
}
Plasmodium falciparum, the etiologic agent of malaria, is a facultative intracellular parasite of the phylum Apicomplexa. A limited turnover of microfilaments takes place beneath the parasite plasma membrane, but the cytoplasm of apicomplexans is virtually devoid of F-actin. We produced Plasmodium actin in yeast. Purified recombinant Plasmodium actin polymerized inefficiently unless both gelsolin and phalloidin were added. The resulting actin polymers appeared fragmented in the fluorescence… CONTINUE READING
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