Unusual prenylated phenols with antioxidant activities from Ganoderma cochlear.

  title={Unusual prenylated phenols with antioxidant activities from Ganoderma cochlear.},
  author={Xingrong Peng and Jie-Qing Liu and Cui Fang Wang and Zhonghui Han and Yi-Fang Shu and Xu-Yang Li and Lin Zhou and Minghua Qiu},
  journal={Food chemistry},

Two rare meroterpenoidal rotamers from Ganoderma applanatum

Applanatumols Z3 (1) and Z4 (2), two novel natural product hybrids consisting of a meroterpenoid and a glycerol and three known compounds (3–5) were isolated from the fruiting bodies of the fungus

Meroterpenoids from Ganoderma Species: A Review of Last Five Years

This review gives an overview of new GMs from genus Ganoderma and their biological activities and biosynthetic pathway, focusing on the period from 2013 until 2018.

(±)-Ganoapplanin, a Pair of Polycyclic Meroterpenoid Enantiomers from Ganoderma applanatum.

Biological studies showed that (±)-1 and its enantiomers exhibited different inhibitory activities on T-type voltage-gated calcium channels, and a plausible biogenetic pathway, involving a key Gomberg-Bachmann reaction, was proposed.



Prenylated phenolics from Ganoderma fornicatum.

Three new prenylated phenolic compounds, fornicins A-C (1-3), were obtained from the fruiting bodies of Ganoderma fornicatum and exhibited moderate cytotoxic activity with IC(50) values of 15 to 30 microg/mL in Hep-2 cells.

Three new triterpenoids containing four-membered ring from the fruiting body of Ganoderma sinense.

Three new triterpenoids with an unusual four-membered ring skeleton produced by a bond across C-1 to C-11 are isolated from the fruiting body of Ganoderma sinense.

Ganomycins A and B, new antimicrobial farnesyl hydroquinones from the basidiomycete Ganoderma pfeifferi.

Two new farnesyl hydroquinones were isolated from Ganoderma pfeifferi and their structures were elucidated by spectroscopic methods, exhibiting antimicrobial activity against several Gram-positive and Gram-negative bacteria.

Inhibition of the dimerization and active site of HIV-1 protease by secondary metabolites from the Vietnamese mushroom Ganoderma colossum.

Kinetic studies using Zhang-Poorman and Lineweaver plots revealed that compound 2 competitively inhibited the active site of the enzyme, whereas the tetracyclic triterpene schisanlactone A, previously isolated from the same fungus, was a dimerization inhibitor.

Lingzhiols, unprecedented rotary door-shaped meroterpenoids as potent and selective inhibitors of p-Smad3 from Ganoderma lucidum.

Biological evaluation showed that Lingzhiol or (-)-lingzhiol could selectively inhibit the phosphorylation of Smad3 in TGF-β1-induced rat renal proximal tubular cells and activate Nrf2/Keap1 in mesangial cells under diabetic conditions.

Isolation and bioactivity evaluation of terpenoids from the medicinal fungus Ganoderma sinense.

Eight new lanostane triterpenoids and a new sesquiterpenoid, ganosinensine, together with eleven known triter penoids, were isolated from the fruiting bodies of the fungus Ganoderma sinense and showed cytotoxic activity and induction ability of hPXR-mediated CYP3A4 expression.

Inhibition of xanthine oxidase by flavonoids.

It is suggested that certain flavonoids might suppress in vivo the formation of active oxygen species and urate by xanthine oxidase.