Unusual polymorphisms in human immunodeficiency virus type 1 associated with nonprogressive infection.

@article{Alexander2000UnusualPI,
  title={Unusual polymorphisms in human immunodeficiency virus type 1 associated with nonprogressive infection.},
  author={Louis Alexander and E E Weiskopf and Thomas Greenough and Nathan C. Gaddis and Marcy R. Auerbach and Michael H Malim and Stephen J. O'Brien and Bruce D. Walker and John L. Sullivan and Ronald C Desrosiers},
  journal={Journal of virology},
  year={2000},
  volume={74 9},
  pages={4361-76}
}
Factors accounting for long-term nonprogression may include infection with an attenuated strain of human immunodeficiency virus type 1 (HIV-1), genetic polymorphisms in the host, and virus-specific immune responses. In this study, we examined eight individuals with nonprogressing or slowly progressing HIV-1 infection, none of whom were homozygous for host-specific polymorphisms (CCR5-Delta32, CCR2-64I, and SDF-1-3'A) which have been associated with slower disease progression. HIV-1 was… CONTINUE READING