Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome.

@article{Zhang1995UnusualPO,
  title={Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome.},
  author={Changqing Zhang and Andrea L Baumer and Ian R. Mackay and A. W. Linnane and Phillip Nagley},
  journal={Human molecular genetics},
  year={1995},
  volume={4 4},
  pages={751-4}
}
Genes in the 16.6 kb human mitochondrial DNA (mtDNA) are concerned exclusively with bioenergy production. Mutations in mtDNA can, therefore, lead to bioenergy decline and so contribute to various age-related degenerative diseases and even to 'natural' ageing (1-3). Large deletions in mtDNA occur in tissues of patients with mitochondrial myopathies and also occur in normal ageing, particularly in postmitotic tissues characterised by high energy demands and low rates of cell division, notably… CONTINUE READING