Unusual pattern of Sonic hedgehog expression in the polydactylous mouse mutant Hemimelic extra-toes.

@article{Blanc2002UnusualPO,
  title={Unusual pattern of Sonic hedgehog expression in the polydactylous mouse mutant Hemimelic extra-toes.},
  author={Isabelle Le Blanc and Antoine Bach and B. Robert},
  journal={The International journal of developmental biology},
  year={2002},
  volume={46 7},
  pages={969-74}
}
We have examined the dynamic expression of Sonic hedgehog (Shh) in limb buds of the Hemimelic extra-toes (Hx) mutant. An ectopic domain of expression appears in the limb bud at embryonic day 11.5, which is not restricted to the anterior mesenchyme as in other polydactylous mutants, but extends along the entire apical ectodermal ridge. No difference in expression was observed between heterozygotes and homozygotes. This ectopic expression domain forms later and is maintained longer than the… CONTINUE READING

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