Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X.

@article{Wang2016UnusualMO,
  title={Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X.},
  author={Jianle Wang and Camille M Syrett and Marianne C. Kramer and Arindam Basu and Michael L Atchison and Montserrat C Anguera},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 14},
  pages={E2029-38}
}
Females have a greater immunological advantage than men, yet they are more prone to autoimmune disorders. The basis for this sex bias lies in the X chromosome, which contains many immunity-related genes. Female mammals use X chromosome inactivation (XCI) to generate a transcriptionally silent inactive X chromosome (Xi) enriched with heterochromatic modifications and XIST/Xist RNA, which equalizes gene expression between the sexes. Here, we examine the maintenance of XCI in lymphocytes from… CONTINUE READING
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Michigan Lupus Cohort

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