Unusual kinetic and structural properties control rapid assembly and turnover of actin in the parasite Toxoplasma gondii.

@article{Sahoo2006UnusualKA,
  title={Unusual kinetic and structural properties control rapid assembly and turnover of actin in the parasite Toxoplasma gondii.},
  author={Nivedita Sahoo and Wandy Beatty and John M Heuser and David Sept and L. David Sibley},
  journal={Molecular biology of the cell},
  year={2006},
  volume={17 2},
  pages={
          895-906
        }
}
Toxoplasma is a protozoan parasite in the phylum Apicomplexa, which contains a number of medically important parasites that rely on a highly unusual form of motility termed gliding to actively penetrate their host cells. Parasite actin filaments regulate gliding motility, yet paradoxically filamentous actin is rarely detected in these parasites. To investigate the kinetics of this unusual parasite actin, we expressed TgACT1 in baculovirus and purified it to homogeneity. Biochemical analysis… CONTINUE READING

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