Unusual hydrate stabilization in the two-dimensional layered structure of quinacrinium bis(2-carboxy-4,5-dichlorobenzoate) tetrahydrate, a proton-transfer compound of the drug quinacrine.

@article{Smith2009UnusualHS,
  title={Unusual hydrate stabilization in the two-dimensional layered structure of quinacrinium bis(2-carboxy-4,5-dichlorobenzoate) tetrahydrate, a proton-transfer compound of the drug quinacrine.},
  author={Graham Smith and U. Wermuth and D. Sagatys},
  journal={Acta crystallographica. Section C, Crystal structure communications},
  year={2009},
  volume={65 Pt 4},
  pages={
          o131-3
        }
}
The crystal structure of the hydrated proton-transfer compound of the drug quinacrine [rac-N'-(6-chloro-2-methoxyacridin-9-yl)-N,N-diethylpentane-1,4-diamine] with 4,5-dichlorophthalic acid, C(23)H(32)ClN(3)O(2+).2C(8)H(3)Cl(2)O(4)(-).4H(2)O, has been determined at 200 K. The four labile water molecules of solvation in the structure form discrete ...O-H...O-H... hydrogen-bonded chains parallel to the quinacrine side chain, the two N-H groups of which act as hydrogen-bond donors for two of the… Expand
4-Methylpyridinium 2-carboxy-4,5-dichlorobenzoate monohydrate
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  • 2012
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References

SHOWING 1-2 OF 2 REFERENCES
A short history of SHELX.
  • G. Sheldrick
  • Chemistry, Medicine
  • Acta crystallographica. Section A, Foundations of crystallography
  • 2008