The repair of large cranial or spinal dural defects has especially been a challenge faced by most neurosurgeons. Repair of dural defects is essential to avoid complications such as permanent cerebrospinal fluid (CSF) leakage, infection, neural herniation and adhesions between neural and overlying tissues . Large dural defects are usually repaired with either autologous graft materials (e.g., periosteum, fascia) or artificial tissues. Using biological graft harvested from the patient takes more time compared to using synthetic graft. Most often the fascia is taken from the same operative field or from distant sites. Silastic membranes are some of the most commonly used dural substitutes whose material is easily fashioned to an appropriate size and shape. They bear no risk of transmissible disease and more importantly, react minimally with adjacent neural tissues . However, the use of silastic dural grafts has potential risks for the recipients. In this article, we report two unusual complications related to dural substitutes in pediatric patients and review the current literature.