Unusual carbon fixation gives rise to diverse polyketide extender units.

  title={Unusual carbon fixation gives rise to diverse polyketide extender units.},
  author={Nick Quade and Liujie Huo and Shwan K. Rachid and Dirk W. Heinz and Rolf M{\"u}ller},
  journal={Nature chemical biology},
  volume={8 1},
Polyketides are structurally diverse and medically important natural products that have various biological activities. During biosynthesis, chain elongation uses activated dicarboxylic acid building blocks, and their availability therefore limits side chain variation in polyketides. Recently, the crotonyl-CoA carboxylase-reductase (CCR) class of enzymes was identified in primary metabolism and was found to be involved in extender-unit biosynthesis of polyketides. These enzymes are, in theory… CONTINUE READING
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