Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc

@article{Wolfe1997UnusualRA,
  title={Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc},
  author={Scot A. Wolfe and Pei Zhou and Volker D{\"o}tsch and Lin Chen and Angie You and Steffan N. Ho and Gerald R Crabtree and Gerhard Wagner and Gregory L. Verdine},
  journal={Nature},
  year={1997},
  volume={385},
  pages={172-176}
}
TRANSCRIPTION factors of the NFAT family regulate the production of effector proteins that coordinate the immune response1. The immunosuppressive drugs FK506 and cyclosporin A (CsA) act by blocking a Ca2+-mediated signalling pathway leading to NFAT. Although FK506 and CsA have enabled human organs to be transplanted routinely, the toxic side-effects of these drugs limit their usage. This toxicity might be absent in antagonists that target NFAT directly. As a first step in the structure-based… CONTINUE READING
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