Untreated illness and outcome of psychosis

@article{Clarke2006UntreatedIA,
  title={Untreated illness and outcome of psychosis},
  author={M. Clarke and P. Whitty and S. Browne and O. McTigue and M. Kamali and M. Gervin and A. Kinsella and J. Waddington and C. Larkin and E. O’Callaghan},
  journal={British Journal of Psychiatry},
  year={2006},
  volume={189},
  pages={235 - 240}
}
Background There has been controversy as to whether early intervention in psychosis can improve the outcome of the disorder. Aims To establish if there is an association between duration of untreated psychosis and the 4-year outcome of persons with a first episode of psychosis. Method Prospective naturalistic follow-up study of the outcome of consecutive first presentations with DSM–IV psychosis attending a community-based psychiatric service. Results A longer duration of untreated psychosis… Expand
Prospective relationship of duration of untreated psychosis to psychopathology and functional outcome over 12years
TLDR
These results provide qualified support for the potential long-term benefit of reduction in the duration of untreated psychosis in terms of improvement in symptoms and functional outcome. Expand
Duration of untreated psychosis: What are we talking about?
TLDR
Duration of untreated psychosis (DUP) broadly refers to the time elapsing between onset of psychosis and treatment initiation, and a lack of consistency in definition is concerning, considering that an absence of consensus on what ‘treatment initiation’ actually comprises could very well be one of the critical factors that so far has not been identified. Expand
Outcome measures in early psychosis
TLDR
The evolution of the concept of DUP is explored, the evidence for its predictive value is synthesised, the problems in measurement are highlighted, and the potential pitfalls are considered. Expand
The association between pre-morbid adjustment, duration of untreated psychosis and outcome in first-episode psychosis
TLDR
Longer DUP is associated with poorer 2-year outcome of psychosis in schizophrenia-spectrum disorders, when pre-morbid functioning and other prognostic factors are controlled for. Expand
Impacts of duration of untreated psychosis on cognition and negative symptoms in first-episode schizophrenia: a 3-year prospective follow-up study
TLDR
Supporting evidence is provided that delayed treatment to first-episode psychosis is associated with poorer cognitive and clinical outcomes and that DUP may specifically affect memory function and its adverse impact on verbal memory may only become evident at a later stage of the recovery process. Expand
Duration of untreated illness as a key to early intervention in schizophrenia: A review
TLDR
Early intervention seems to ensure a shortened DUP, especially for people presenting with brief limited intermittent psychotic symptoms, and, ultimately, ensure a more favorable prognosis for patients affected by SCZ. Expand
Duration of Untreated Psychosis, Referral Route, and Age of Onset in an Early Intervention in Psychosis Service and a Local CAMHS.
TLDR
It is suggested that the involvement of child and adolescent teams is vital to the work of early intervention in psychosis services, with particular focus on service-level variables and pathways to care. Expand
Illness characteristics and symptoms in an Irish early intervention for psychosis service
TLDR
Symptom onset in a youth FEP sample frequently occurs before age 18 years, and the findings support the provision of adequate strategies for management of negative symptom deficits and substance abuse across all ages in FEP. Expand
Predictors of outcome in first-episode schizophrenia over the first 4 years of illness
TLDR
The outcome of schizophrenia may not be as pessimistic as once thought and most patients did not display a downward deteriorating course of illness and the relationship between DUP and outcome beyond the early stages of illness is supported. Expand
The role of treatment delay in predicting 5-year outcomes in an early intervention program
Background Past research on the relationship between treatment delay and outcomes for first-episode psychosis has primarily focused on the role of duration of untreated psychosis (DUP) in predictingExpand
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TLDR
Investigation of the relationship between untreated initial psychosis duration and quality of life, symptom severity, and time to remission of positive symptoms in neuroleptic-naive patients with DSM-IV schizophrenia found that earlier age at illness onset was associated with longer duration of untreated prodromal psychotic symptoms. Expand
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TLDR
Duration of psychosis before treatment may be an important predictor of outcome in first-episode schizophrenia, and is significantly associated with time to remission as well as with level of remission. Expand
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TLDR
A longer DUP was associated with more pronounced negative, positive and general psychopathological symptoms as well as a lower global functioning 15 years after the first psychiatric admission, even after effects of other factors related to the long-term outcome were controlled for. Expand
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TLDR
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Is there an association between duration of untreated psychosis and 24-month clinical outcome in a first-admission series?
TLDR
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Background. Relatively few predictors of outcome in first-episode psychosis are potentially malleable and duration of untreated psychosis (DUP) is one. However, the degree to which DUP is mediated byExpand
Premorbid functioning versus duration of untreated psychosis in 1 year outcome in first-episode psychosis
TLDR
The findings strengthen the rationale for establishing health service programs for early detection and treatment of first-onset psychosis and to a limited degree premorbid functioning and DUP interact, but DUP has an independent influence on outcome. Expand
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TLDR
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TLDR
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TLDR
Evidence thus far suggests that DUP may be related to ease of reducing psychotic symptoms once treatment begins for first episode patients, but there is no evidence of a relationship to likelihood of relapse. Expand
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