Untersuchung neuronaler Korrelate der Fingermotorik mit der funktionellen Magnetresonanztomographie (fMRT) bei Patienten mit idiopathischem Parkinson-Syndrom

  title={Untersuchung neuronaler Korrelate der Fingermotorik mit der funktionellen Magnetresonanztomographie (fMRT) bei Patienten mit idiopathischem Parkinson-Syndrom},
  author={C. Wurster},


From intention to action: motor cortex and the control of reaching movements.
  • J. Kalaska
  • Psychology, Medicine
  • Advances in experimental medicine and biology
  • 2009
This chapter surveys some of the neurophysiological evidence supporting the role of the motor cortex, with particular focus on the latter, more 'traditional', role of motor cortex. Expand
Update on the pathogenesis of Parkinson’s disease
  • J. Schulz
  • Biology, Medicine
  • Journal of Neurology
  • 2008
Three underlying pathogenetic pathways can be identified and cell death is executed by excitotoxicity, apoptosis and autophagy and appears to be facilitated by neuroinflammatory processes. Expand
Task specific influences of Parkinson’s disease on the striato-thalamo-cortical and cerebello-thalamo-cortical motor circuitries
In this first fMRI study of twins discordant for PD, the data support the hypothesis that BG- cortical and cerebellar-cortical pathways are task-specifically influenced by PD. Expand
Functional changes in the activity of cerebellum and frontostriatal regions during externally and internally timed movement in Parkinson's disease
Between-group comparison indicates that PD patients OFF medication may compensate for their basal ganglia-cortical loop's dysfunction using different motor pathways involving cerebellum and basalganglia relays during the two phases of rhythmic movement. Expand
Parallel organization of functionally segregated circuits linking basal ganglia and cortex.
The basal ganglia serve primarily to integrate diverse inputs from the entire cerebral cortex and to "funnel" these influences, via the ventrolateral thalamus, to the motor cortex. Expand
Neuronal firing in the globus pallidus internus and the ventrolateral thalamus related to parkinsonian motor symptoms.
The results support the view that abnormal neuronal activity in GPi and Vop/Vim are involved in the pathophysiology of parkinsonism. Expand
Parametric analysis of rate-dependent hemodynamic response functions of cortical and subcortical brain structures during auditorily cued finger tapping: a fMRI study
Functional magnetic resonance imaging was performed during a finger-tapping task in response to acoustic stimuli and data indicate different cerebellar contributions to motor control at frequencies below or above about 3 Hz, respectively. Expand
Pharmacologically modulated fMRI--cortical responsiveness to levodopa in drug-naive hemiparkinsonian patients.
These data are in accordance with the hypothesis that, in de novo idiopathic hemiparkinsonian syndrome, motor cortex hypoactivation in contralateral M1 and bilateral SMA is caused by a decreased input from the subcortical motor loop, which is reversible by L-dopa. Expand
Differential Contributions of Motor Cortex, Basal Ganglia, and Cerebellum to Speech Motor Control: Effects of Syllable Repetition Rate Evaluated by fMRI
Functional magnetic resonance imaging findings corroborate the suggestion of a differential impact of various cortical and subcortical areas on speech motor control. Expand
Event-related functional magnetic resonance imaging in Parkinson's disease before and after levodopa.
It is concluded that levodopa improves impaired motor initiation in the supplementary motor area and decreases hyperfunction of lateral premotor and M1 associated with Parkinson's disease during simple volitional movements. Expand