Untangling the tau gene association with neurodegenerative disorders.

@article{Pittman2006UntanglingTT,
  title={Untangling the tau gene association with neurodegenerative disorders.},
  author={Alan M. Pittman and Hon Chung Fung and R. Erandie Ediriweera De Silva},
  journal={Human molecular genetics},
  year={2006},
  volume={15 Spec No 2},
  pages={R188-95}
}
Pathological tau protein inclusions have long been recognized to define the diverse range of neurodegenerative disorders called the tauopathies, which include Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and frontotemporal lobar degeneration. Mutations in the tau gene, MAPT, cause familial frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), and common variation in MAPT is strongly associated with the risk of PSP, corticobasal degeneration and, to a… CONTINUE READING

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Increased MAPT expression is associated with progressive supranuclear palsy

  • A. Pittman, A. Myers, J. Hardy, N. Wood, A. Lees, R. de Silva
  • Alzh. Dement.,
  • 2006

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