Untangling the Web: specific signaling from PKC isoforms to MAPK cascades.

  title={Untangling the Web: specific signaling from PKC isoforms to MAPK cascades.},
  author={Angela Clerk and Peter H. Sugden},
  journal={Circulation research},
  volume={89 10},
The understanding of intracellular signaling pathways and their physiological effects has been confounded by the existence of numerous isoforms of the various signaling components. Thus, many families of protein kinases comprise several subfamilies, each of which may contain multiple isoforms deriving from distinct genetic loci. Furthermore, each locus may produce multiple products through alternative splicing. A rational argument maintains that each isoform has a distinct role in cellular… CONTINUE READING

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