Untangling the Manganese-α-Synuclein Web

  title={Untangling the Manganese-α-Synuclein Web},
  author={Tanara V Peres and Nancy L. Parmalee and Ebany J. Martinez-Finley and Michael Aschner},
  booktitle={Front. Neurosci.},
Neurodegenerative diseases affect a significant portion of the aging population. Several lines of evidence suggest a positive association between environmental exposures, which are common and cumulative in a lifetime, and development of neurodegenerative diseases. Environmental or occupational exposure to manganese (Mn) has been implicated in neurodegeneration due to its ability to induce mitochondrial dysfunction, oxidative stress, and α-synuclein (α-Syn) aggregation. The role of the α-Syn… CONTINUE READING


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