Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases

  title={Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases},
  author={Michael P. Mazanetz and Peter M. Fischer},
  journal={Nature Reviews Drug Discovery},
Aggregation of hyperphosphorylated tau is one of the characteristic neuropathological lesions of Alzheimer's disease and other neurodegenerative disorders. Pharmacological modulation of tau hyperphosphorylation might represent a valid and feasible therapeutic strategy for such disorders. Here, we consider recent evidence supporting the validity of the three most relevant kinases affecting tau hyperphosphorylation — GSK3β, CDK5 and ERK2 — as drug targets and describe progress in the design of… CONTINUE READING
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