# Unsupervised discovery of temporal sequences in high-dimensional datasets, with applications to neuroscience

@article{Mackevicius2018UnsupervisedDO,
title={Unsupervised discovery of temporal sequences in high-dimensional datasets, with applications to neuroscience},
author={Emily L Mackevicius and Andrew H Bahle and Alex H. Williams and Shijie Gu and Natalia I Denissenko and Mark S. Goldman and Michale S. Fee},
journal={bioRxiv},
year={2018}
}
The ability to identify interpretable, low-dimensional features that capture the dynamics of large-scale neural recordings is a major challenge in neuroscience. Dynamics that include repeated temporal patterns (which we call sequences), are not succinctly captured by traditional dimensionality reduction techniques such as principal components analysis (PCA) and non-negative matrix factorization (NMF). The presence of neural sequences is commonly demonstrated using visual display of trial… Expand
11 Citations
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