Unsupervised detection of genes of influence in lung cancer using biological networks

@article{Goldenberg2011UnsupervisedDO,
  title={Unsupervised detection of genes of influence in lung cancer using biological networks},
  author={Anna Goldenberg and Sara Mostafavi and Gerald Quon and Paul C. Boutros and Quaid D Morris},
  journal={Bioinformatics},
  year={2011},
  volume={27 22},
  pages={
          3166-72
        }
}
MOTIVATION Lung cancer is often discovered long after its onset, making identifying genes important in its initiation and progression a challenge. By the time the tumors are discovered, we only observe the final sum of changes of the few genes that initiated cancer and thousands of genes that they have influenced. Gene interactions and heterogeneity of samples make it difficult to identify genes consistent between different cohorts. Using gene and gene-product interaction networks, we propose a… CONTINUE READING
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