Unstructured hydrophilic sequences in prokaryotic proteomes correlate with dehydration tolerance and host association.

@article{Kriko2010UnstructuredHS,
  title={Unstructured hydrophilic sequences in prokaryotic proteomes correlate with dehydration tolerance and host association.},
  author={Anita Kri{\vs}ko and Zlatko Smole and Gaelle Debret and Nela Nikoli{\'c} and Miroslav Radman},
  journal={Journal of molecular biology},
  year={2010},
  volume={402 5},
  pages={775-82}
}
Water loss or desiccation is among the most life-threatening stresses. It leads to DNA double-strand breakage, protein aggregation, cell shrinkage, and low water activity precluding all biological functions. Yet, in all kingdoms of life, rare organisms are resistant to desiccation through prevention or reversibility of such damage. Here, we explore possible hallmarks of prokaryotic desiccation tolerance in their proteomes. The content of unstructured, low complexity (LC) regions was analyzed in… CONTINUE READING