Unstructured 5′-tails act through ribosome standby to override inhibitory structure at ribosome binding sites

@inproceedings{Sterk2018Unstructured5A,
  title={Unstructured 5′-tails act through ribosome standby to override inhibitory structure at ribosome binding sites},
  author={Maaike Sterk and C{\'e}dric Romilly and E Gerhart H Wagner},
  booktitle={Nucleic acids research},
  year={2018}
}
Initiation is the rate-limiting step in translation. It is well-known that stable structure at a ribosome binding site (RBS) impedes initiation. The ribosome standby model of de Smit and van Duin, based on studies of the MS2 phage coat cistron, proposed how high translation rates can be reconciled with stable, inhibitory structures at an RBS. Here, we revisited the coat protein system and assessed the translation efficiency from its sequestered RBS by introducing standby mutations. Further… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS
1 Citations
77 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 77 references

A Prelude to Translational (Re)Initiation

  • M. H. de Smit, J. van Duin
  • Translation Mechanisms. Landes Bioscience…
  • 2003
Highly Influential
14 Excerpts

Similar Papers

Loading similar papers…