Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F.

@article{Bomont2005UnstableMC,
  title={Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F.},
  author={Pascale Bomont and Paul S Maddox and Jagesh V. Shah and Arshad B Desai and Don W Cleveland},
  journal={The EMBO journal},
  year={2005},
  volume={24 22},
  pages={
          3927-39
        }
}
Centromere protein F (CENP-F) (or mitosin) accumulates to become an abundant nuclear protein in G2, assembles at kinetochores in late G2, remains kinetochore-bound until anaphase, and is degraded at the end of mitosis. Here we show that the absence of nuclear CENP-F does not affect cell cycle progression in S and G2. In a subset of CENP-F depleted cells, kinetochore assembly fails completely, thereby provoking massive chromosome mis-segregation. In contrast, the majority of CENP-F depleted… CONTINUE READING
BETA

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 67 CITATIONS

FILTER CITATIONS BY YEAR

2005
2019

CITATION STATISTICS

  • 5 Highly Influenced Citations

  • Averaged 4 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Similar Papers

Loading similar papers…