Unstable cellular differentiation in adenosquamous cell carcinoma.

  title={Unstable cellular differentiation in adenosquamous cell carcinoma.},
  author={Vernon E. Steele and Paul Nettesheim},
  journal={Journal of the National Cancer Institute},
  volume={67 1},
For the determination of whether two or more stem lines with fixed of stable differentiation are present in a growing mixed adenosquamous cell carcinoma, two different mixed tumors, derived from transformed F344 rat tracheal epithelium, were dissociated and ten single cells were isolated from each tumor. Each of these single cells was allowed to grow 27 population doublings to form a clonal population. All clones were then inoculated into animals for the assessment of in vivo differentiation… CONTINUE READING


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