Unstable B7-H4 cell surface expression and T-cell redirection as a means of cancer therapy.

Abstract

Tumor immune regulation has been demonstrated in clinical studies using antibodies targeted to the B7/CD28 family. B7 homolog 4 (B7-H4) negatively regulates immune responses and is overexpressed in many types of human cancer, indicating that B7-H4 may be a potential target of cancer therapy. B7-H4 expression is affected by the microenvironment, and its… (More)
DOI: 10.3892/or.2016.5084

Topics

6 Figures and Tables

Cite this paper

@article{Iizuka2016UnstableBC, title={Unstable B7-H4 cell surface expression and T-cell redirection as a means of cancer therapy.}, author={Akira Iizuka and Ryota Kondou and Chizu Nonomura and Tadashi Ashizawa and Keiichic Ohshima and Masatoshi Kusuhara and Mitsuhiro Isaka and Yasuhisa Ohde and Ken Yamaguchi and Yasuto Akiyama}, journal={Oncology reports}, year={2016}, volume={36 5}, pages={2625-2632} }