Unsolved problems and future perspectives of hepatitis B virus vaccination.

  title={Unsolved problems and future perspectives of hepatitis B virus vaccination.},
  author={Kazuto Tajiri and Yukihiro Shimizu},
  journal={World journal of gastroenterology},
  volume={21 23},
Hepatitis B virus (HBV) infection is still a serious worldwide problem, and vaccination is the most effective strategy for primary prevention of the infection. Although universal vaccination may be required for total eradication, several countries, including Japan, have not yet adopted universal vaccination programs. Some individuals are non-responders to HBV vaccine and several mechanisms responsible for their poor response have been proposed. To overcome non-response, third generation… CONTINUE READING
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